{"id":1031707,"date":"2022-10-11T02:07:37","date_gmt":"2022-10-11T06:07:37","guid":{"rendered":"https:\/\/www.immortalitymedicine.tv\/up-regulation-of-mir-133a-3p-promotes-ovary-insulin-resistance-on-granulosa-cells-of-obese-pcos-patients-via-inhibiting-pi3k-akt-signaling-bmc\/"},"modified":"2024-08-17T15:10:04","modified_gmt":"2024-08-17T19:10:04","slug":"up-regulation-of-mir-133a-3p-promotes-ovary-insulin-resistance-on-granulosa-cells-of-obese-pcos-patients-via-inhibiting-pi3k-akt-signaling-bmc","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/human-reproduction\/up-regulation-of-mir-133a-3p-promotes-ovary-insulin-resistance-on-granulosa-cells-of-obese-pcos-patients-via-inhibiting-pi3k-akt-signaling-bmc.php","title":{"rendered":"Up-regulation of miR-133a-3p promotes ovary insulin resistance on granulosa cells of obese PCOS patients via inhibiting PI3K\/AKT signaling &#8211; BMC&#8230;"},"content":{"rendered":"<p><p>Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS, et al. Polycystic ovary syndrome. Nat Rev Dis Primers. 2016;2:16057.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Diamanti-Kandarakis E, Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev. 2012;33:9811030.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Yilmaz B, Vellanki P, Ata B, Yildiz BO. Diabetes mellitus and insulin resistance in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis. Fertil Steril. 2018;110:52333.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Tagliaferri V, Romualdi D, Immediata V, De Cicco S, Di Florio C, Lanzone A, et al. Metformin vs myoinositol: which is better in obese polycystic ovary syndrome patients? A randomized controlled crossover study. Clin Endocrinol. 2017;86:72530.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Zhu QL, Zuo R, He YP, Wang Y, Chen ZJ, Sun Y, et al. Local regeneration of cortisol by 11-HSD1 contributes to insulin resistance of the granulosa cells in PCOS. J Clin Endocrinol Metab. 2016;101:jc20153899.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:28197.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Ambros V. microRNAs: tiny regulators with great potential. Cell. 2001;107:8236.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Sun KL, Lai EC. Adult-specific functions of animal microRNAs. Nat Rev Genet. 2013;14:53548.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Min KH, Yang WM, Lee W. Saturated fatty acids-induced miR-424-5p aggravates insulin resistance via targeting insulin receptor in hepatocytes. Biochem Biophys Res Commun. 2018;503:158793.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Massart J, Sjgren RJO, Lundell LS, Mudry JM, Franck N, OGorman DJ, et al. Altered miR-29 expression in Type 2 diabetes influences glucose and lipid metabolism in skeletal muscle. Diabetes. 2017;66:180718.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Xu G, Ji C, Song G, Zhao C, Shi C, Song L, et al. MiR-26b modulates insulin sensitivity in adipocytes by interrupting the PTEN\/PI3K\/AKT pathway. Int J Obes (Lond). 2015;39:152330.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Yamasaki T, Yoshino H, Enokida H, Hidaka H, Chiyomaru T, Nohata N, et al. Novel molecular targets regulated by tumor suppressors microRNA-1 and microRNA-133a in bladder cancer. Int J Oncol. 2012;40:182130.<\/p>\n<p>CAS    PubMed                        Google Scholar                <\/p>\n<p>Gallagher IJ, Scheele C, Keller P, Nielsen AR, Remenyi J, Fischer CP, et al. Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. Genome Med. 2010;2(2):9.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Zou X, Lu TT, Zhao ZF, Liu GB, Lian ZQ, Guo YQ, et al. Comprehensive analysis of mRNAs and miRNAs in the ovarian follicles of uniparous and multiple goats at estrus phase. BMC Genom. 2020;21:267.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Shah K, Patel SS. Phosphatidylinositide-3 kinase: a newer molecular target in metabolic and hormonal pathway of polycystic ovary syndrome. Exp Clin Endocrinol Diabetes. 2014;122:2617.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Wu C, Feng J, Ke W, Jiang Z. Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5-reduc-tase type 1 in PCOS rats. Sci Rep. 2018;8:7982.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Belani M, Deo A, Shah P, Banker M, Singal P, Gupta S. Differential insulin and steroidogenic signaling in insulin resistant and non- insulin resistant human luteinized granulosa cells-a study in PCOS patients. J Steroid Biochem Mol Biol. 2018;178:28392.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Eshre\/Asrm T. The Rotterdam ESHRE\/ASRM-sponsored PCOS Consensus-Workshop Group: Revised. consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2003;2004(19):417.<\/p>\n<p>                    Google Scholar                <\/p>\n<p>Tang YB, Pan JC, Huang S, Peng XS, Zou XN, Luo YX, et al. Downregulation of miR-133a-3p promotes prostate cancer bone metastasis via activating PI3K\/AKT signaling. J Exp Clin Cancer Res. 2018;37:160.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Barber TM, Hanson P, Weickert MO, Franks S. Obesity and polycystic ovary syndrome: implications for pathogenesis and novel management strategies. Clin Med Insights Reprod Health. 2019;13:1179558119874042.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Morgan CL, Jenkins-Jones S, Currie CJ, Rees DA. Evaluation of adverse outcome in young women with polycystic ovary syndrome versus matched, reference controls: a retrospective, observational study. J Clin Endocrinol Metab. 2012;97:325160.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Talmor A, Dunphy B. Female obesity and infertility. Best Pract Res Clin Obstet Gynaecol. 2015;29:498506.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Mulder CL, Lassi ZS, Grieger JA, Ali A, Jankovic-Karasoulos T, Roberts CT, et al. Cardio-metabolic risk factors among young infertile women: a systematic review and meta-analysis. BJOG Int J Obstet Gynaecol. 2020;127:930.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Tamer Erel C, Senturk LM. The impact of body mass index on assisted reproduction. Curr Opin Obstet Gynecol. 2009;21:22835.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Broughton DE, Moley KH. Obesity and female infertility: potential mediators of obesitys impact. Fertil Steril. 2017;107:8407.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Hou Y, Wang YQ, Xu SM, Qi GM, Wu XQ. Bioinformatics identification of microRNAs involved in polycystic ovary syndrome based on microarray data. Mol Med Rep. 2019;20:28191.<\/p>\n<p>CAS    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Wang KH, Zhang XR, Yang XM. Expression and clinical significance of three miRNAs in serum of phlegm-dampness syndrome in polycystic ovary syndrome. China Arch Tradit China Med. 2020;38:2731.<\/p>\n<p>                    Google Scholar                <\/p>\n<p>Ge Y, Wang KH, Wang XD. Study on the expression level of miRNA-2861 in the follicular fluid of patients with phlegm-dampness polycystic ovary syndrome. J Liaoning Univ Tradit Chin Med. 2020;22:748.<\/p>\n<p>                    Google Scholar                <\/p>\n<p>McGinnis LK, Luense LJ, Christenson LK. MicroRNA in ovarian biology and disease. Csh Perspect Med. 2015;5: a022962.<\/p>\n<p>                    Google Scholar                <\/p>\n<p>Petersen MC, Shulman GI. Mechanisms of insulin action and insulin resistance. Physiol Rev. 2018;98:2133223.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Wu CY, Jiang F, Wei K, Jiang ZL. Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5-reductase type 1 in PCOS rats. SciRep. 2018;8:7982.<\/p>\n<p>                    Google Scholar                <\/p>\n<p>Hou N, Mai YP, Qiu XX, Yuan WC, Li YL, Luo CF, et al. Carvacrol attenuates diabetic cardiomyopathy by modulating the PI3K\/AKT\/GLUT4 pathway in diabetic mice. Front Pharmacol. 2019;10:998.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Liang ZX, Liu Z, Cheng C, Wang H, Deng XJ, Liu JH, et al. VPS33B interacts with NESPCOS group to modulate EGFR\/PI3K\/AKT\/c-Myc\/P53\/miR-133a-3p signaling and induce 5-fluorouracil sensitivity in nasopharyngeal carcinoma. Cell Death Dis. 2019;10:305.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Shen WJ, Wu XK. The biological effects of ovary insulin resistance. J Pract Obstet Gynecol. 2010;26:56972.<\/p>\n<p>                    Google Scholar                <\/p>\n<p><!-- Auto Generated --><\/p>\n<p>Visit link:<br \/>\n<a target=\"_blank\" href=\"https:\/\/bmcwomenshealth.biomedcentral.com\/articles\/10.1186\/s12905-022-01994-6\" title=\"Up-regulation of miR-133a-3p promotes ovary insulin resistance on granulosa cells of obese PCOS patients via inhibiting PI3K\/AKT signaling - BMC...\" rel=\"noopener\">Up-regulation of miR-133a-3p promotes ovary insulin resistance on granulosa cells of obese PCOS patients via inhibiting PI3K\/AKT signaling - BMC...<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p> Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS, et al. Polycystic ovary syndrome <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/human-reproduction\/up-regulation-of-mir-133a-3p-promotes-ovary-insulin-resistance-on-granulosa-cells-of-obese-pcos-patients-via-inhibiting-pi3k-akt-signaling-bmc.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246857],"tags":[],"class_list":["post-1031707","post","type-post","status-publish","format-standard","hentry","category-human-reproduction"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1031707"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1031707"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1031707\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1031707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1031707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1031707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}