BACKGROUND<\/p>\n
More than half of recurrent pregnancy loss (RPL) remains unexplained. We hypothesized that women with a history of unexplained RPL (URPL) have low venous reserve.<\/p>\n
METHODS<\/p>\n
Case–control study in 12 women with a history of URPL, 11 healthy nulliparous controls and 12 primiparous controls with a history of uncomplicated pregnancy. To quantify venous reserve, we measured plasma volume (PV, ml\/m2<\/sup>) and venous compliance in forearm and calf (VCarm<\/SUB>, VCcalf<\/SUB>, (ml\/dl)\/mmHg) during the follicular phase of the menstrual cycle. Mean arterial blood pressure (mmHg) was measured by oscillometry. Arterial demand was evaluated by cardiac index (CI, (l\/min)\/m2<\/sup>).<\/p>\n RESULTS<\/p>\n Baseline characteristics were comparable between groups. All groups had similar CI. Women with a history of RPL had 14% and 9% lower mean PV compared with nulliparous and primiparous controls (P<\/I> < 0.01 and P<\/I> = 0.04, respectively). In women with URPL, the mean VCarm<\/SUB> was 25% and 32% lower compared with nulliparous and primiparous controls (P<\/I> = 0.04 and P<\/I> < 0.01, respectively), while the mean VCcalf<\/SUB> was 29 and 22% lower compared with the two control groups (P<\/I> < 0.01 and P<\/I> = 0.03, respectively).<\/p>\n CONCLUSIONS<\/p>\n Women with URPL have lower venous reserves when compared with controls at comparable arterial demand. Interventions that increase venous reserve may improve pregnancy outcome.<\/p>\n Source: BACKGROUND More than half of recurrent pregnancy loss (RPL) remains unexplained. We hypothesized that women with a history of unexplained RPL (URPL) have low venous reserve. METHODS Case–control study in 12 women with a history of URPL, 11 healthy nulliparous … Continue reading
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