BACKGROUND<\/p>\n
To investigate the long-term changes in health-related quality of life (HRQOL) after uterine artery embolization (UAE) for symptomatic fibroids, we conducted a prospective cohort study.<\/p>\n
METHODS<\/p>\n
Eighty-two women completed the validated uterine fibroid symptom and QOL (UFS-QOL) questionnaire before UAE. Short-term results after a median of 8 months (range: 3–20) have been published previously. Patients were asked to complete the questionnaire again after a median of 6.3 years (range: 5–7.6). Secondary outcome measures were the frequency of additional surgical or endovascular procedures due to treatment failure and the menstrual status.<\/p>\n
RESULTS<\/p>\n
A total of 4\/82 patients (5%) were lost to follow-up. Of the remaining 78 patients, 11 underwent surgery or repeat UAE (hysterectomy n<\/I> = 6, myomectomy n<\/I> = 1, UAE n<\/I> = 4) at a median of 13 months (range: 5–70) after UAE. Two patients failed clinically but did not undergo a second intervention. The overall treatment failure rate 6 years after UAE was 17%. Clinical long-term follow-up regarding symptom control and quality of life was available in the remaining 65 patients. Symptom severity scores decreased from a median of 37.50 (quartile range, QR: 28.13–53.13) to 0.00 (QR: 0.00–10.94) (P<\/I> < 0.001), whereas the HRQOL total score increased from a median of 64.66 (QR: 46.34–79.10) to 100.00 (QR: 96.12–100.00) (P<\/I>< 0.001). Both scores also improved significantly compared with short-term results (P<\/I>= 0.006 and P<\/I>= 0.041). Permanent amenorrhea was observed in five patients at a median of 18 months (range: 10–46) after UAE and at a mean patient age of 50 years.<\/p>\n
CONCLUSIONS<\/p>\n
UAE leads to durable relief of fibroid-related symptoms and sustained improvement in HRQOL. After 6 years, clinical failure can be expected in 17%, and most of these patients require secondary invasive treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"
BACKGROUND To investigate the long-term changes in health-related quality of life (HRQOL) after uterine artery embolization (UAE) for symptomatic fibroids, we conducted a prospective cohort study. METHODS Eighty-two women completed the validated uterine fibroid symptom and QOL (UFS-QOL) questionnaire before … Continue reading