BACKGROUND<\/p>\n
The optimal ovarian stimulation dose to obtain the best balance between the probability of pregnancy and the risk of complications, while maximizing cost-effectiveness of in vitro<\/I> fertilization (IVF) treatment, is yet to be established.<\/p>\n
METHODS<\/p>\n
A systematic search of the electronic databases PubMed, EMBASE and Cochrane library, from 1984 until October 2009 for randomized controlled trials comparing different doses of recombinant FSH in IVF, was performed.<\/p>\n
RESULTS<\/p>\n
Ten studies (totaling 1952 IVF cycles) were included in the present meta-analysis, comprising patients younger than 39 years with regular menstrual cycle, normal basal FSH levels and two normal ovaries. Comparison was made between studies using a daily dose of 100 versus 200 IU recFSH, and between 150 versus 200 IU recFSH or higher. Although oocyte yield was greater in the >200 IU\/day dose group, pregnancy rates were similar compared with lower dose groups. The risk of insufficient response to ovarian stimulation was greatest in the 100 IU\/day dose group. The risk of developing ovarian hyperstimulation syndrome was greater in the >200 IU\/day dose group. The number of embryos available for cryopreservation was lowest in the 100 IU\/day group, but similar comparing the 150 IU\/day and the >200 IU\/day dose groups.<\/p>\n
CONCLUSIONS<\/p>\n
This meta-analysis suggests that the optimal daily recFSH stimulation dose is 150 IU\/day in presumed normal responders younger than 39 years undergoing IVF. Compared with higher doses, this dose is associated with a slightly lower oocyte yield, but similar pregnancy and embryo cryopreservation rates. Furthermore, the wide spread adherence to this optimal dose will allow for a considerable reduction in IVF costs and complications.<\/p>\n","protected":false},"excerpt":{"rendered":"
BACKGROUND The optimal ovarian stimulation dose to obtain the best balance between the probability of pregnancy and the risk of complications, while maximizing cost-effectiveness of in vitro fertilization (IVF) treatment, is yet to be established. METHODS A systematic search of … Continue reading