BACKGROUND<\/p>\n
Low-dose aspirin therapy could improve remodelling of maternal spiral arteries during early placentation and prevent subsequent pregnancy-related hypertensive disorders. We investigated whether low-dose aspirin therapy reduces the incidence of hypertensive pregnancy complications in unselected IVF and ICSI patients when medication was started prior to pregnancy.<\/p>\n
METHODS<\/p>\n
A total of 487 patients who underwent IVF\/ICSI were randomized to receive 100 mg aspirin (n<\/I> = 242) or placebo (n<\/I> = 245) daily, starting on the first day of gonadotrophin stimulation. Pregnant women continued the medication until delivery. A total of 107 patients (52 with aspirin and 55 with placebo) experienced live birth and were included in this follow-up study. The main outcome measure was the incidence of hypertensive pregnancy complications.<\/p>\n
RESULTS<\/p>\n
Embryo transfer took place in 227 (94%) women in the aspirin group and in 229 (93%) women in the placebo group. The live birth rate between the aspirin (22.9%) and placebo (24.0%) groups did not differ significantly (P<\/I> = 0.78). The overall incidence of hypertensive pregnancy complications was 15.4% (8\/52) in the aspirin group and 18.2% (10\/55) in the placebo group (P<\/I> = 0.70, 95% confidence interval for the difference of proportions –17 to 11%). There were two cases of severe pre-eclampsia in the aspirin group and three cases in the placebo group.<\/p>\n
CONCLUSIONS<\/p>\n
In the present study, the incidence of hypertensive pregnancy complications did not differ statistically significantly between low-dose aspirin and placebo groups in unselected IVF\/ICSI patients, when medication was started concomitantly with gonadotrophin stimulation and continued until delivery.<\/p>\n
The study was registered at clinicaltrials.gov. NCT00683202.<\/p>\n","protected":false},"excerpt":{"rendered":"
BACKGROUND Low-dose aspirin therapy could improve remodelling of maternal spiral arteries during early placentation and prevent subsequent pregnancy-related hypertensive disorders. We investigated whether low-dose aspirin therapy reduces the incidence of hypertensive pregnancy complications in unselected IVF and ICSI patients when … Continue reading