{"id":1027933,"date":"2024-02-09T02:32:52","date_gmt":"2024-02-09T07:32:52","guid":{"rendered":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/uncategorized\/genome-wide-association-study-identifies-human-genetic-variants-associated-with-fatal-outcome-from-lassa-fever-nature-com.php"},"modified":"2024-02-09T02:32:52","modified_gmt":"2024-02-09T07:32:52","slug":"genome-wide-association-study-identifies-human-genetic-variants-associated-with-fatal-outcome-from-lassa-fever-nature-com","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/human-genetics\/genome-wide-association-study-identifies-human-genetic-variants-associated-with-fatal-outcome-from-lassa-fever-nature-com.php","title":{"rendered":"Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever &#8211; Nature.com"},"content":{"rendered":"<p><p>        Merson, L. et al. Clinical characterization of Lassa fever:        a systematic review of clinical reports and research to        inform clinical trial design. PLoS Negl. Trop. Dis.        15, e0009788 (2021).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Kenmoe, S. et al. Systematic review and meta-analysis of        the epidemiology of Lassa virus in humans, rodents and        other mammals in sub-Saharan Africa. PLoS Negl. Trop.        Dis. 14, e0008589 (2020).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        McCormick, J. B. & Fisher-Hoch, S. P. Lassa fever. Curr.        Top. Microbiol. Immunol. 262, 75109 (2002).      <\/p>\n<p>        CAS PubMed                Google Scholar      <\/p>\n<p>        Okogbenin, S. et al. Retrospective cohort study of Lassa        fever in pregnancy, southern Nigeria. Emerg. Infect.        Dis. 25, 14941500 (2019).      <\/p>\n<p>        Article PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Happi, A. N. et al. Increased prevalence of Lassa fever        virus-positive rodents and diversity of infected species        found during human Lassa fever epidemics in Nigeria.        Microbiol. Spectr. 10, e0036622 (2022).      <\/p>\n<p>        Article        PubMed                Google Scholar      <\/p>\n<p>        Gire, S. K. et al. Epidemiology. Emerging disease or        diagnosis?. Science 338, 750752 (2012).      <\/p>\n<p>        Article ADS CAS PubMed                Google Scholar      <\/p>\n<p>        McCormick, J. B., Webb, P. A., Krebs, J. W., Johnson, K. M.        & Smith, E. S. A prospective study of the epidemiology and        ecology of Lassa fever. J. Infect. Dis. 155,        437444 (1987).      <\/p>\n<p>        Article CAS PubMed                Google Scholar      <\/p>\n<p>        Lassa Fever (CDC, 2019); <a href=\"https:\/\/www.cdc.gov\/vhf\/lassa\/index.html\" rel=\"nofollow\">https:\/\/www.cdc.gov\/vhf\/lassa\/index.html<\/a>      <\/p>\n<p>        Radoshitzky, S. R. & de la Torre, J. C. Human pathogenic        arenaviruses (Arenaviridae). in Encyclopedia of        Virology 507 (Elsevier, 2019).      <\/p>\n<p>        Lassa Fever Annual Epidemiological Report for 2019        (European Centre for Disease Prevention and Control, 2021);                <a href=\"https:\/\/www.ecdc.europa.eu\/en\/publications-data\/lassa-fever-annual-epidemiological-report-2019\" rel=\"nofollow\">https:\/\/www.ecdc.europa.eu\/en\/publications-data\/lassa-fever-annual-epidemiological-report-2019<\/a>      <\/p>\n<p>        Okokhere, P. et al. Clinical and laboratory predictors of        Lassa fever outcome in a dedicated treatment facility in        Nigeria: a retrospective, observational cohort study.        Lancet Infect. Dis. 18, 684695 (2018).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Andersen, K. G. et al. Clinical sequencing uncovers origins        and evolution of Lassa virus. Cell 162,        738750 (2015).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Chapman, S. J. & Hill, A. V. S. Human genetic        susceptibility to infectious disease. Nat. Rev.        Genet. 13, 175188 (2012).      <\/p>\n<p>        Article CAS PubMed                Google Scholar      <\/p>\n<p>        COVID-19 Host Genetics Initiative. Mapping the human        genetic architecture of COVID-19. Nature 600,        472477 (2021).      <\/p>\n<p>        Article                Google Scholar      <\/p>\n<p>        Tian, C. et al. Genome-wide association and HLA region        fine-mapping studies identify susceptibility loci for        multiple common infections. Nat. Commun. 8,        599 (2017).      <\/p>\n<p>        Article        ADS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Sabeti, P. C. et al. Genome-wide detection and        characterization of positive selection in human        populations. Nature 449, 913918 (2007).      <\/p>\n<p>        Article ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Andersen, K. G. et al. Genome-wide scans provide evidence        for positive selection of genes implicated in Lassa fever.        Philos. Trans. R. Soc. Lond. B 367, 868877        (2012).      <\/p>\n<p>        Article CAS         Google Scholar      <\/p>\n<p>        Jae, L. T. et al. Deciphering the glycosylome of        dystroglycanopathies using haploid screens for Lassa virus        entry. Science 340, 479483 (2013).      <\/p>\n<p>        Article ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Kunz, S. et al. Posttranslational modification of        alpha-dystroglycan, the cellular receptor for arenaviruses,        by the glycosyltransferase LARGE is critical for virus        binding. J. Virol. 79, 1428214296 (2005).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Raabe, V. & Koehler, J. Laboratory diagnosis of Lassa        fever. J. Clin. Microbiol. 55, 16291637        (2017).      <\/p>\n<p>        Article CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Ackerman, H. et al. A comparison of casecontrol and        family-based association methods: the example of        sickle-cell and malaria. Ann. Hum. Genet. 69,        559565 (2005).      <\/p>\n<p>        Article        CAS PubMed                Google Scholar      <\/p>\n<p>        Hill, A. V. S. Aspects of genetic susceptibility to human        infectious diseases. Annu. Rev. Genet. 40,        469486 (2006).      <\/p>\n<p>        Article        CAS PubMed                Google Scholar      <\/p>\n<p>        Bowen, M. D. et al. Genetic diversity among Lassa virus        strains. J. Virol. 74, 69927004 (2000).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Siddle, K. J. et al. Genomic analysis of Lassa virus during        an increase in cases in Nigeria in 2018. N. Engl. J.        Med. 379, 17451753 (2018).      <\/p>\n<p>        Article CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Boisen, M. L. et al. Field validation of recombinant        antigen immunoassays for diagnosis of Lassa fever. Sci.        Rep. 8, 5939 (2018).      <\/p>\n<p>        Article        ADS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Johnson, K. M. et al. Clinical virology of Lassa fever in        hospitalized patients. J. Infect. Dis. 155,        456464 (1987).      <\/p>\n<p>        Article CAS PubMed                Google Scholar      <\/p>\n<p>        Cummins, D. et al. Acute sensorineural deafness in Lassa        fever. JAMA 264, 20932096 (1990).      <\/p>\n<p>        Article        CAS PubMed                Google Scholar      <\/p>\n<p>        McCormick, J. B. et al. A casecontrol study of the        clinical diagnosis and course of Lassa fever. J. Infect.        Dis. 155, 445455 (1987).      <\/p>\n<p>        Article CAS PubMed                Google Scholar      <\/p>\n<p>        Monath, T. P. Lassa fever: review of epidemiology and        epizootiology. Bull. World Health Organ. 52,        577592 (1975).      <\/p>\n<p>        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Shaffer, J. G. et al. Lassa fever in post-conflict Sierra        Leone. PLoS Negl. Trop. Dis. 8, e2748 (2014).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Klingstrm, J. & Ahlm, C. Sex, gender, and hemorrhagic        fever viruses. in Sex and Gender Differences in        Infection and Treatments for Infectious Diseases (eds        Klein, S. L. & Roberts, C. W.) 211230 (Springer        International, 2015).      <\/p>\n<p>        McCormick, J. B. Epidemiology and control of Lassa fever.        Curr. Top. Microbiol. Immunol. 134, 6978        (1987).      <\/p>\n<p>        CAS PubMed                Google Scholar      <\/p>\n<p>        Webb, P. A. et al. Lassa fever in children in Sierra Leone,        West Africa. Trans. R. Soc. Trop. Med. Hyg.        80, 577582 (1986).      <\/p>\n<p>        Article        CAS PubMed                Google Scholar      <\/p>\n<p>        Zhou, W. et al. Efficiently controlling for casecontrol        imbalance and sample relatedness in large-scale genetic        association studies. Nat. Genet. 50,        13351341 (2018).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Tucker, G., Price, A. L. & Berger, B. Improving the power        of GWAS and avoiding confounding from population        stratification with PC-Select. Genetics 197,        10451049 (2014).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Kanai, M., Tanaka, T. & Okada, Y. Empirical estimation of        genome-wide significance thresholds based on the 1000        Genomes Project data set. J. Hum. Genet. 61,        861866 (2016).      <\/p>\n<p>        Article CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Eeles, R. A. et al. Multiple newly identified loci        associated with prostate cancer susceptibility. Nat.        Genet. 40, 316321 (2008).      <\/p>\n<p>        Article CAS PubMed                Google Scholar      <\/p>\n<p>        Deeb, R., Veerapandiyan, A., Tawil, A. & Treidler, S.        Variable penetrance of AndersenTawil Syndrome in a        Caucasian family with a rare missense KCJN2 mutation        (P3.450). Neurology 90, Number 15_supplement        (2018).      <\/p>\n<p>        Howe, K. L. et al. Ensembl 2021. Nucleic Acids Res.        49, D884D891 (2021).      <\/p>\n<p>        Article CAS PubMed                Google Scholar      <\/p>\n<p>        Sakabe, S., Witwit, H., Khafaji, R., Cubitt, B. & de la        Torre, J. C. Chaperonin TRiC\/CCT participates in        mammarenavirus multiplication in human cells via        interaction with the viral nucleoprotein. J. Virol.        97, e0168822 (2023).      <\/p>\n<p>        Article PubMed                Google Scholar      <\/p>\n<p>        Sugita, S. et al. A stoichiometric complex of neurexins and        dystroglycan in brain. J. Cell Biol. 154,        435445 (2001).      <\/p>\n<p>        Article CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Mittal, R., Kumar, A., Ladda, R., Mainali, G. & Aliu, E.        Pitt Hopkins-like syndrome 1 with novel CNTNAP2 mutation in        siblings. Child Neurol. Open 8,        2329048X211055330 (2021).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Song, J.-M. et al. Pathogenic GRM7 mutations associated        with neurodevelopmental disorders impair axon outgrowth and        presynaptic terminal development. J. Neurosci.        41, 23442359 (2021).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Wang, J. et al. SARS-CoV-2 uses metabotropic glutamate        receptor subtype 2 as an internalization factor to infect        cells. Cell Discov. 7, 119 (2021).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Wang, J. et al. Metabotropic glutamate receptor subtype 2        is a cellular receptor for rabies virus. PLoS        Pathog. 14, e1007189 (2018).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Rogoz, K. et al. Identification of a neuronal receptor        controlling anaphylaxis. Cell Rep. 14,        370379 (2016).      <\/p>\n<p>        Article        CAS PubMed                Google Scholar      <\/p>\n<p>        Klotz, L. & Enz, R. MGluR7 is a presynaptic metabotropic        glutamate receptor at ribbon synapses of inner hair cells.        FASEB J. 35, e21855 (2021).      <\/p>\n<p>        Article CAS PubMed                Google Scholar      <\/p>\n<p>        Mateer, E. J., Huang, C., Shehu, N. Y. & Paessler, S. Lassa        fever-induced sensorineural hearing loss: a neglected        public health and social burden. PLoS Negl. Trop.        Dis. 12, e0006187 (2018).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Christianson, J., Oxford, J. T. & Jorcyk, C. L. Emerging        perspectives on leukemia inhibitory factor and its receptor        in cancer. Front. Oncol. 11, 693724 (2021).      <\/p>\n<p>        Article CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Tewhey, R. et al. Direct identification of hundreds of        expression-modulating variants using a multiplexed reporter        assay. Cell 165, 15191529 (2016).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        1000 Genomes Project Consortium et al. A global reference        for human genetic variation. Nature 526,        6874 (2015).      <\/p>\n<p>        Jia, X. et al. Imputing amino acid polymorphisms in human        leukocyte antigens. PLoS ONE 8, e64683        (2013).      <\/p>\n<p>        Article        ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Gourraud, P.-A. et al. HLA diversity in the 1000 genomes        dataset. PLoS ONE 9, e97282 (2014).      <\/p>\n<p>        Article        ADS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p><!-- Auto Generated --><\/p>\n<p>See the rest here:<\/p>\n<p><a target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01589-3\" title=\"Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever - Nature.com\" rel=\"noopener\">Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever - Nature.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p> Merson, L. et al <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/human-genetics\/genome-wide-association-study-identifies-human-genetic-variants-associated-with-fatal-outcome-from-lassa-fever-nature-com.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[4],"tags":[],"class_list":["post-1027933","post","type-post","status-publish","format-standard","hentry","category-human-genetics"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1027933"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1027933"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1027933\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1027933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1027933"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1027933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}