Human genetic variation recent, varies among populations

ScienceDaily (Nov. 28, 2012) Nearly three-quarters of mutations in genes that code for proteins — the workhorses of the cell — occurred within the past 5,000 to 10,000 years, fairly recently in evolutionary terms, said a national consortium of genomic and genetic experts, including those at Baylor College of Medicine. Continue reading

Bone marrow stem cell therapy does not improve short-term recovery after heart attack

Washington, November 8 (ANI): Administering to patients stem cells derived from their own bone marrow either three or seven days after a heart attack is safe but does not improve heart function six months later, according to a clinical trial. Continue reading

Stem cell therapy using patient's own cells after heart attack does not enhance cardiac recovery

Public release date: 6-Nov-2012 [ | E-mail | Share ] Contact: Steve Goodyear sgoodyear@mhif.org 952-807-8365 Minneapolis Heart Institute Foundation MINNEAPOLIS, MN November 6, 2012 Administering autologous stem cells obtained from bone marrow either 3 or 7 days following a heart attack did not improve heart function six months later, reports a new clinical trial supported by the National Institutes of Health. The results of this trial, called TIME (Transplantation In Myocardial Infarction Evaluation), were presented by Jay Traverse, MD of the Minneapolis Heart Institute Foundation Tuesday, Nov. Continue reading

Surprising findings from NHLBI Exome Sequencing Project reported

Public release date: 6-Nov-2012 [ | E-mail | Share ] Contact: Cathy Yarbrough press@ashg.org 858-243-1814 American Society of Human Genetics A multi-institutional team of researchers has sequenced the DNA of 6,700 exomes, the portion of the genome that contains protein-coding genes, as part of the National Heart, Lung and Blood Institute (NHLBI)-funded Exome Sequencing Project, one of the largest medical sequencing studies ever undertaken. Scientists participating in the project initially expected that individual rare variants would have a greater effect on over 80 heart, lung and blood related traits and diseases of high public health significance, said Suzanne M. Leal, Ph.D., professor and director, Center for Statistical Genetics in the Department of Molecular and Human Genetics of Baylor College of Medicine in Houston, TX. Continue reading

Researcher hunts for sickle cell anemia cure with gene targeting, stem cells

Halfway around the world in India, Sivaprakash Ramalingam had heard of Johns Hopkins researchers using a promising new technique for gene therapy that he hoped to integrate with stem cells to cure diseases. After getting a doctorate in biochemistry in his native country, he came to Baltimore four years ago to study under the technique’s pioneer, Srinivasan Chandrasegaran, at Hopkins’ Bloomberg School of Public Health. Continue reading